Changes of MODY signal pathway genes in the endoplasmic reticulum stress in INS-1-3 cells.
ObjectiveMetabolic disturbances induce endoplasmic reticulum stress (ERS) in pancreatic beta cells.This study aims to investigate whether a common pathway exists in the ERS induced by various chemicals, including high levels of glucose and palmitate in INS-1-3 cells.MethodERS in INS-1-3 cells was induced by exposure cells to thapsigargin (TG), tuni